Leflunomide CAS: 75706-12-6 Soo saaraha Soo saaraha

Leflunomide waa daawo afka laga heli karo oo wax ka beddeleysa cudur-ka-hortagga xanuunka waxaana loo bilaabay sidii Arava gudaha Mareykanka si loogu daweeyo rheumatoid arthritis-ka (RA);waa daawada kaliya ee ugu horeysa oo la tilmaamo si loo yareeyo burburka wadajirka ah ee RA, sidaas darteed wax ka qabashada baahida caafimaad ee aan la daboolin. Leflunomide waa dawo-yaqaan oo si degdeg ah oo gebi ahaanba u metabolized (nolosha nus, <60 daqiiqo) ka dib afka. maamulka teriflunomide, farmashiyoolaji firfircoon α-cyanoenol metabolite.

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Codsiga iyo Saamaynta

Leflunomide waa mid aan firfircoonayn, laakiin teriflunomide waxay xakameysaa pyrimidine de novo synthesis ee qiyaasaha daweynta ee hooseeya iyada oo la xakameynayo dihydrorotate dehydrogenase (heerka go'aaminta enzyme ee isku dhafka UMP), hoos u dhigista DNA iyo RNA synthesis, iyo xiritaanka wareegga wareegga unugyada iyo soo saarista unugyada difaaca jirka.Yaraynta dihydroorotate ilaa orotate waxay dhacdaa si isku mid ah iyada oo la dhimayo cofactor, ubiquinone (coenzyme Q).Xakamaynta dihydrorotate dehydrogenase by teriflunomide waxay muujinaysaa kinetics aan tartan iyo tartan lahayn.Maamulka leflunomide ee bukaanada qaba rheumatoid arthritis-ku wuxuu keenaa ka saarida joogtada ah ee unugyada B iyo hoos u dhigista habka difaaca jirka.