4-Nitrofenyl Beta-D-glucuronide CAS: 10344-94-2

Ogaanshaha dhaqdhaqaaqa β-glucuronidase: 4-NPBG waxaa badanaa loo isticmaalaa sida substrate-ka koromojiinka si loo qiimeeyo joogitaanka iyo waxqabadka β-glucuronidase ee muunado noole oo kala duwan.Insaymku wuxuu jebiyaa isku-xidhka glycosidic ee 4-NPBG, isagoo soo saaraya 4-nitrophenol, kaas oo lagu cabbiri karo iyadoo la isticmaalayo spectrophotometry.

Daraasadaha dheef-shiid kiimikaadka daroogada: Maadaama β-glucuronidase ay door muhiim ah ka ciyaarto dheef-shiid kiimikaadka dawooyinka iyo xenobiotics, 4-NPBG waxaa loo isticmaali karaa in lagu qiimeeyo waxqabadka enzyme-kan ee daraasadaha dheef-shiid kiimikaadka daroogada.Waxay ka caawisaa fahamka xadka iyo kinetics ee falcelinta glucuronidation, kuwaas oo muhiim u ah nadiifinta daroogada iyo bioavailability.

Daraasadaha Sunta: Qaar ka mid ah xeryahooda sunta ah waa la dheef-shiidin karaa oo laga soo saari karaa qaabka isku-dhafka glucuronide.Adigoo isticmaalaya 4-NPBG substrate ahaan, cilmi-baarayaashu waxay baari karaan waxqabadka β-glucuronidase ee unugyo kala duwan ama xariiqyada unugyada si ay u qiimeeyaan sunta suurtagalka ah ama saameynta xun ee xeryahooda.

Baadhista kiliinikada: Cabbirka waxqabadka β-glucuronidase iyadoo la adeegsanayo 4-NPBG waxaa lagu isticmaali karaa goobaha caafimaadka si loo ogaado cudurrada ama xaaladaha qaarkood.Heerarka aan caadiga ahayn ama dhaqdhaqaaqa β-glucuronidase ayaa laga yaabaa inay muujiyaan cilladaha hidda-socodka qaarkood, shaqada beerka, ama kansarka.