Tirzepatide CAS: 2023788-19-2 Soo saaraha

Tirzepatide waxaa loo sameeyay sidii laba-geesood oo labadaba GLP-1 iyo gaastric inhibitory polypeptide (GIP) reseptors (Frias et al., 2018).Si la mid ah GLP-1, GIP waa hoormoon incretin oo u shaqeeya si ay u keento dheecaanka insulin.Tirzepatide waxay ku jirtaa horumarinta wajiga 3 ee dadka waaweyn ee leh cayilka ama cayilka oo leh miisaan la xidhiidha miisaanka oo hadda ku jira dib-u-eegis nidaamsan sida daaweynta dadka waaweyn ee qaba nooca 2 ee sonkorowga. .Waxa kale oo loo bartay daawaynta suurtogalka ah ee steatohepatitis-ka aan khamriga ahayn (NASH) iyo wadna xanuunka oo leh jajab ka saarid la ilaaliyo (HFpEF).

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Codsiga iyo Saamaynta

Tirzepatide waxaa loo isticmaalaa cunto iyo barnaamij jimicsi oo habboon si loo xakameeyo sonkorta dhiigga oo sarreeya dadka qaba nooca 2aad ee sonkorowga.Xakamaynta sonkorta dhiigga oo sareysa waxay caawisaa ka hortagga dhaawaca kelyaha, indho la'aanta, dhibaatooyinka dareemayaasha, luminta lugaha, iyo dhibaatooyinka shaqada galmada. hyperglycemia marka la barbar dhigo GLP-1 agonist receptor ah oo la doortay.Daraasadaha calaamadaynta ayaa muujiyay in tani ay sabab u tahay tirzepatide oo ku dayanaya ficillada GIP ee dabiiciga ah ee soo-dhoweynta GIP.