Tofacitinib CAS:477600-75-2 Alaab-qeybiyaha

Tofacitinib waa daawo loogu talagalay daaweynta rheumatoid arthritis (RA), psoriasis, cudurka mindhicirka bararka, iyo cudurrada kale ee difaaca jirka, iyo sidoo kale ka hortagga diidmada xubinta taranka. Waa joojiye enzyme Janus kinase 3 (JAK3), taasoo macnaheedu yahay inay farageliso marinka calaamadaynta JAK-STAT kaas oo macluumaadka ka baxsan unugga u gudbiya xudunta unugga, taasoo saameynaysa qoraalka DNA-da. Dhawaan waxaa lagu muujiyay qaabka murqaha ee arthritis-ka la aasaasay, tofacitinib si dhakhso ah ayuu u hagaajiyay cudurka isagoo hor istaagaya soo saarista dhexdhexaadiyeyaasha bararka iyo xakamaynta hiddo-wadaha ku tiirsan STAT1 ee unugyada kala-goysyada. Waxtarkan qaabkan cudurka wuxuu la xiriiray joojinta labada waddo ee calaamadaynta JAK1 iyo 3, taasoo soo jeedinaysa in tofacitinib uu ka faa'iidaysan karo daaweyn iyada oo loo marayo waddooyin aan gaar u ahayn joojinta JAK3.