Simvastatin CAS: 79902-63-9 Soo saaraha soo saaraha

Simvastatin waa semi-synthetic, waxoogaa ka badan hydrophobic, analoogga lovastatin.Sida lovastatin, simvastatin waa horjooge gaar ah oo HMG-CoA reductase ah waxaana loo isticmaalaa daawayn si loo yareeyo kolestaroolka LDL.Dhawaanahan, statins-yadu waxay noqdeen baarayaal bayoolaji oo muhiim ah.Ku lug lahaanshaha ay ku leeyihiin dhacdooyin badan ayaa lala xiriirin karaa qaabkooda asaasiga ah, si kastaba ha ahaatee, habka ficilka ee saameynaha kale ee badan ayaa ah mid aan muuqan.Simvastatin waa xakameyn gaar ah oo HMG-CoA reductase ah, enzim kaas oo kicinaya beddelka HMG-CoA Mevalonate, oo ah tallaabo hore ee biosynthesis kolesteroolka.Waxaa loo isticmaalaa daawaynta hypercholesterolemia, maadaama ay hoos u dhigto heerarka lipoprotein-ka cufnaanta hoose iyo triglycerides, waxayna kor u qaadaysaa heerarka lipoprotein-cufnaanta sare.