Simvastatin CAS:79902-63-9 Bixiyaha Soo-saaraha

Simvastatin waa nus-synthetic, xoogaa hydrophobic ah, oo ah analog lovastatin. Sida lovastatin, simvastatin waa joojiye gaar ah oo HMG-CoA reductase ah waxaana loo isticmaalaa daaweyn ahaan si loo yareeyo kolestaroolka LDL. Dhawaanahan, statins-ku waxay noqdeen baaritaanno bayoolaji oo muhiim ah oo ku saabsan bayoolajiyada unugyada. Ku lug lahaanshahooda dhacdooyin badan waxaa lala xiriirin karaa qaabkooda ficil ee aasaasiga ah, si kastaba ha ahaatee, habka ficilka ee saameyno kale oo badan ma cadda. Simvastatin waa joojiye gaar ah oo HMG-CoA reductase ah, enzyme-ka kiciya beddelka HMG-CoA una beddelo mevalonate, tallaabo hore oo ku saabsan biosynthesis-ka kolestaroolka. Waxaa loo isticmaalaa daaweynta hypercholesterolemia, maadaama ay yareyso heerarka lipoproteins-ka cufnaanta hooseeya iyo triglycerides, waxayna kor u qaaddaa heerarka lipoprotein-ka cufnaanta sare leh.