Fmoc-D-Asn(Trt)-OH CAS:180570-71-2

Fmoc-D-Asn(Trt)-OH waa qalab muhiim u ah isku-darka peptide, gaar ahaan sameynta peptides-ka ka kooban D-enantiomer ee asparagine si sax ah. Kooxda ilaalinta Fmoc waxay ilaalisaa kooxda amino, iyadoo hubinaysa falcelinta xulashada inta lagu jiro isku-xidhka peptide, halka kooxda trityl ay ku darto lakab dheeraad ah oo ilaalin ah. Cilmi-baarayaashu waxay si ballaaran u isticmaalaan Fmoc-D-Asn(Trt)-OH si ay u sameeyaan peptides-ka codsiyada kala duwan, oo ay ku jiraan horumarinta daawada, walxaha bayoolajiga, iyo naqshadeynta peptides-ka firfircoon ee leh qaab-dhismeed gaar ah oo stereochemical ah. La jaanqaadkeeda hababka isku-darka peptide-ka caadiga ah, labadaba istiraatiijiyadaha wejiga adag iyo marxaladda xalka, waxay kor u qaadaysaa kala-duwanaanshaheeda dadaallada cilmi-baarista ee kala duwan. Ka saarista la xakameeyey ee kooxaha ilaalinta waxay u oggolaanaysaa ku-darka istaraatiijiyadeed ee D-asparagine taxanaha peptide, iyadoo ballaarinaysa dib-u-soo-celinta peptide-yada la isku-dhafan karo. Intaa waxaa dheer, Fmoc-D-Asn(Trt)-OH waxay u aragtaa faa'iido ku jirta isku-darka peptides-ka cilmi-baarista proteomics iyo barashada hababka unugyada. Isticmaalka istaraatiijiyadeed ee kooxda ilaalinta trityl wuxuu suurtogal ka dhigayaa in si sax ah loo maareeyo falcelinta D-asparagine, isagoo siinaya cilmi-baarayaasha qalab qiimo leh oo loogu talagalay naqshadeynta peptides-ka oo leh wax-ka-beddello loo habeeyay. Marka la soo koobo, Fmoc-D-Asn(Trt)-OH waxay u taagan tahay aalad badan oo aan laga maarmi karin oo ku jirta kiimikada peptide-ka, taasoo awood siinaysa cilmi-baarayaasha inay sahamiyaan oo ay wax ka beddelaan falcelinta D-asparagine ee loogu talagalay codsiyo cilmiyeed oo ballaaran, gaar ahaan diiradda saarista peptides-ka ka kooban asiidhyada D-amino.