Fmoc-Arg(Tos)-OH CAS:83792-47-6

Fmoc-Arg(Tos)-OH waxay door muhiim ah ka ciyaartaa isku-darka peptide-ka, gaar ahaan marka loo baahdo ilaalin sax ah oo nitrogen guanidine ah oo ku jirta arginine. Kooxda ilaalinta Fmoc waxay ilaalisaa kooxda amino-ka, iyadoo hubinaysa falcelinta xulashada ah inta lagu jiro isku-xidhka peptide-ka, halka kooxda tosyl-ka ee nitrogen guanidine-ka ay bixiso lakab dheeraad ah oo ilaalin ah. Cilmi-baarayaashu waxay isticmaalaan Fmoc-Arg(Tos)-OH si ay u sameeyaan peptide-yada wax-ka-beddello gaar ah oo guanidine ah, taasoo saameyn ku yeelanaysa hawlahooda bayoolojiga ah. Habka ilaalinta laba-geesoodka ah wuxuu suurtogal ka dhigayaa maaraynta la xakameeyey ee fal-celinta guanidine, taasoo ka dhigaysa isku-darkan mid qiimo leh oo ku jira naqshadeynta peptide-yada daraasadaha antimicrobial-ka, isku-xidhka bioconjugation, iyo kiimikada daawada. Iswaafajinta Fmoc-Arg(Tos)-OH oo leh hababka isku-darka peptide-ka caadiga ah, oo ay ku jiraan isku-darka peptide-ka wejiga adag (SPPS), waxay kor u qaadaysaa faa'iidadiisa. Isku-darkani wuxuu helaa codsi ku saabsan dhismaha peptide-yada baaritaannada bayoolojiga, helitaanka daawada, iyo horumarinta agabka ku salaysan peptide-ka. Ka saarista kooxaha ilaalinta ee la xakameeyey waxay u oggolaanaysaa isku-darka istaraatiijiyadeed ee arginine oo leh guanidine wax laga beddelay, taasoo gacan ka geysanaysa kala duwanaanshaha peptides-ka la samayn karo. Marka la soo koobo, Fmoc-Arg (Tos)-OH waxay u taagan tahay aalad gaar ah oo kala duwan oo ku jirta kiimikada peptide-ka, taasoo awood siinaysa cilmi-baarayaasha inay sahamiyaan oo ay wax ka beddelaan fal-celinta guanidine ee codsiyada sayniska iyo daaweynta kala duwan.