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2′-O-Methyluridine CAS:2140-76-3 Qiimaha Soo-saaraha
2′-O-Methyluridine waa nukliyoside wax laga beddelay oo ka kooban koox methyl ah oo ku taal booska 2′ ee giraanta ribose. Waa baloog dhisme oo muhiim ah oo ku jira isku-darka molecules-ka RNA ee wax laga beddelay waxaana lagu bartay sifooyinka bayoolojiga iyo dawooyinka ee suurtagalka ah. Qaar ka mid ah codsiyada la soo sheegay waxaa ka mid ah isticmaalkeeda cilmi-baarista RNA, iyadoo qayb ka ah soo saarista RNA wax laga beddelay ee loogu talagalay codsiyada daaweynta iyo kuwa shaqada, iyo qalab ahaan daraasadda qaab-dhismeedka iyo shaqada RNA.
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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS:951-77-9
2′-Deoxycytidine waa nukliyeoside ka samaysan nukliyeobase cytosine oo ku xiran sonkorta deoxyribose. Waa qayb muhiim ah oo ka mid ah DNA-da waxayna door muhiim ah ka ciyaartaa kaydinta macluumaadka hidde-sidaha iyo gudbinta noolaha nool.
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Cytidine-5′-monophosphate (CMP), aashito bilaash ah CAS:63-37-6
Cytidine 5'-monophosphate (CMP) waa nukleotide u adeegta sidii baloog dhisme oo loogu talagalay isku-darka iyo wax-ka-beddelka RNA. Waa qayb muhiim ah oo ka mid ah dhismaha molecules-ka RNA waxayna ku lug leedahay hababka sida capping mRNA iyo metabolism-ka nucleotide. CMP waxaa sidoo kale loo isticmaalaa cilmi-baarista bayoolojiga iyo molecular-ka ee codsiyada sida qoraalka in vitro iyo calaamadaynta nucleic acid. Doorkeeda dheef-shiid kiimikaadka RNA iyo isticmaalkeeda farsamooyinka tijaabada ee kala duwan ayaa ka dhigaya qalab muhiim ah oo lagu fahmo qaab-dhismeedka iyo shaqada molecules-ka RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
3-isobutyl-1-methylxanthine, oo sidoo kale loo yaqaan IBMX, waa nooc ka mid ah methylxanthine oo si caadi ah loogu isticmaalo cilmi-baarista sayniska isagoo ah joojiye aan gaar ahayn oo ka mid ah phosphodiesterases-ka cyclic nucleotide. Waxaa la ogyahay inay kordhiso heerarka gudaha ee AMP-ga wareegga ah (cAMP) iyo GMP-ga wareegga ah (cGMP) iyadoo la joojinayo burburkooda, taasoo iyaduna beddeli karta waddooyinka kala duwan ee calaamadaynta unugyada.
Marka laga soo tago codsiyada cilmi-baarista, IBMX waxaa loo isticmaalay goobo caafimaad qaarkood si loogu isticmaalo saameynteeda bronchodilator iyo vasodilator. Si kastaba ha ahaatee, isticmaalkeeda daawada aadanaha waa mid xaddidan.
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4-Nitrophenyl phosphate disodium milix hexahydrate CAS:4264-83-9
4-Nitrophenyl phosphate disodium milix hexahydrate waa isku-dhis kiimiko ah oo inta badan loo isticmaalo cilmi-baarista kiimikada iyo dawooyinka. Waa qaab cusbo ah oo ka kooban 4-nitrophenyl phosphate, oo ka kooban laba sodium ion iyo lix molecules biyo ah. Isku-darkan waxaa badanaa loo isticmaalaa sidii substrate loogu talagalay baaritaannada phosphatase iyo daraasadda kinetics-ka ensaymka.
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5′-Deoxy-5-fluorocytidine CAS:66335-38-4
5′-Deoxy-5-fluorocytidine waa nukliyeoside analoog ah oo la sameeyay oo lagu baarayo waxqabadka fayraska ee suurtagalka ah, gaar ahaan fayraska RNA sida fayraska hepatitis C (HCV) iyo flaviviruses. Waxay ka shaqeysaa faragelinta taranka walxaha hidde-sidaha fayraska, ugu dambeyntiina waxay ka hortagtaa awoodda fayrasku u leeyahay inuu ku tarmo oo ku faafo jirka dhexdiisa.
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Cytidine-5′-triphosphate (CTP), cusbo disodium ah CAS:652154-13-7
Cusbada disodium-ka ee Cytidine-5′-triphosphate (CTP), waa triphosphate nucleoside ah oo u adeegta sidii baloog dhisme oo loogu talagalay isku-darka RNA. Waxay door muhiim ah ka ciyaartaa dheef-shiid kiimikaadka unugyada waxayna lagama maarmaan u tahay wareejinta macluumaadka hidde-sidaha ee DNA-da una gudubta RNA inta lagu jiro qoraalka. CTP si weyn ayaa loogu isticmaalaa cilmi-baarista bayoolajiga molecular-ka, gaar ahaan daraasadaha la xiriira isku-darka RNA, faragelinta RNA, iyo hababka kale ee la xiriira RNA. Intaa waxaa dheer, waxaa loo isticmaalaa falcelinta enzymatic, daraasadaha dheef-shiid kiimikaadka nucleotide, iyo substrate-ka baaritaannada bayoolaji ee kala duwan. Warshadaha dawooyinka, CTP waxay sidoo kale yeelan kartaa codsiyo suurtagal ah oo ku saabsan horumarinta daawooyinka fayraska ka hortagga iyo kuwa ka hortagga kansarka.
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ITP, inosine 5′-triphosphate trisodium milix CAS:35908-31-7
Cusbada trisodium-ka Inosine-5′-triphosphate, oo inta badan loo soo gaabiyo ITP-Na3, waa qaab triphosphate ah oo inosine ah, oo ah nucleoside oo door muhiim ah ka ciyaara hababka kala duwan ee bayoolojiga. Isku-darkani waa qaab milix ah, taasoo ka dhigaysa mid biyo-milmi kara oo ku habboon in loo isticmaalo baaritaannada bayoolaji iyo enzymatic, iyo sidoo kale cilmi-baarista bayoolojiga molecular. Cusbada trisodium-ka Inosine-5′-triphosphate waxaa loo isticmaalaa barashada falgallada enzymatic, isku-beddelka nucleotide, iyo substrate ahaan enzymes-ka qaarkood. Adeegsigeedu wuxuu sidoo kale ku fidsan yahay daraasadaha analoogga nucleotide iyo qayb ka mid ah diyaarinta isku-darka nucleotide ee loo isticmaalo farsamooyinka bayoolojiga molecular.
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5-Bromouracil CAS:51-20-7 Qiimaha Soo-saaraha
5-Bromouracil waa nooc ka mid ah uracil oo macmal ah, kaas oo ah qayb ka mid ah RNA. 5-Bromouracil waxaa lagu dari karaa asiidhyada nucleic-ga waxayna sababi kartaa isbeddello iyadoo si khaldan ula jaanqaadaysa guanine inta lagu jiro taranka DNA-da. Waxaa loo isticmaalaa sidii isbeddel hidde-side si loo barto heerarka isbeddelka iyo farsamooyinka.
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5-Fluoro-2′-deoxyuridine CAS:50-91-9
5-Fluoro-2′-deoxyuridine waa nukliyoside analoog ah oo isku-dhafan oo joojiya isku-darka DNA-da. Waxaa lagu bartay sifooyinka ka hortagga fayraska iyo ka hortagga burooyinka. Intaa waxaa dheer, waxaa loo isticmaalaa qalab cilmi-baaris ah oo ku saabsan bayoolajiga molecular-ka iyo bayoolajiga.
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Cusbo disodium ah oo Cytidine-5′-triphosphate ah CAS:36051-68-0
Cusbada disodium-ka Cytidine-5′-triphosphate (CTP-Na2) waa triphosphate-ka nucleoside kaas oo u adeega sidii baloog dhisme oo ku jira isku-darka RNA. Waxay door muhiim ah ka ciyaartaa dheef-shiid kiimikaadka unugyada, iyadoo u adeegta sidii substrate-ka polymerase-ka RNA ee qoraalka iyo sidii ilo tamar oo loogu talagalay falgallada ensaymyada kala duwan. CTP-Na2 waxaa badanaa loo isticmaalaa cilmi-baarista bayoolojiga iyo molecular-ka iyadoo qayb ka ah falgallada ku lug leh isku-darka RNA, wax-ka-beddelka, iyo nidaaminta. Qaabkeeda cusbada disodium wuxuu kordhiyaa milmidiisa xalalka biyaha, taasoo ka dhigaysa mid aad ugu habboon isticmaalka shaybaarka.
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Aashitada Ribonucleic ee laga helo Baker's Yeast CAS:63231-63-0
Aashitada Ribonucleic (RNA) ee ka timaadda khamiirka Baker, oo sidoo kale loo yaqaan Saccharomyces cerevisiae, waxay tilmaamaysaa molecules-ka RNA-ga ee ku jira fangaskan hal-unuglaha ah ee caadiga ah. Waxay u adeegtaa hawlo kala duwan oo muhiim ah oo ku jira unugga, oo ay ku jiraan isku-darka borotiinka, dhaqdhaqaaqa ensaymikada, iyo nidaaminta hiddaha. RNA-ga ka yimaada khamiirka Baker wuxuu xiiso u leeyahay saynisyahannada iyo cilmi-baarayaasha baranaya bayoolajiga molecular-ka, hidde-sideyaasha, iyo hababka unugyada. Waxaa loo isticmaalaa tijaabooyin iyo daraasado ballaaran si loo helo aragtiyo ku saabsan muujinta hiddaha, habaynta RNA, iyo hababka molecular-ka ee hoos yimaada hawlaha unugyada.
