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guanosine 5′- (disodium dihydrogen triphosphate) CAS:56001-37-7
Guanosine-5′-triphosphate disodium waa isku-dhis loo isticmaalo habab kala duwan oo bayoolaji ah, sida isku-darka RNA iyo DNA, iyo sidoo kale marinnada wareejinta calaamadaha. Waa triphosphate nucleoside ah, taasoo la macno ah inay ka kooban tahay guanosine nucleoside ah oo ku xiran saddex kooxood oo fosfate ah. Qaabka milixda disodium wuxuu si fudud u tilmaamayaa inay tahay milix ka kooban laba ion oo sodium ah.
Isku-darkani waa mid muhiim u ah wareejinta tamarta unugyada wuxuuna ku lug leeyahay falgallo kala duwan oo ensaym ah. Sidoo kale waa isha tamarta ee isku-darka borotiinka iyo hababka kale ee unugyada.
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2′-Deoxyuridine CAS:951-78-0 Qiimaha Soo-saaraha
2′-Deoxyuridine waa nukliyeoside ka kooban nukliyeobase uracil oo ku xiran sonkorta deoxyribose. Waa qayb muhiim ah oo ka mid ah dhismaha DNA-da waxayna ku lug leedahay taranka iyo qorista walxaha hidde-sidaha. 2′-Deoxyuridine waxaa loo isticmaalaa cilmi-baarista sayniska iyadoo ah horudhac u ah isku-darka DNA-da iyo farsamooyinka bayoolajiga ee kala duwan. Waxay door muhiim ah ka ciyaartaa fahamka hababka hidde-sidaha, iyo sidoo kale horumarinta codsiyada daaweynta ee suurtagalka ah ee meelaha sida daaweynta fayraska iyo daaweynta kansarka.
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Adenosine5′-(trihydrogen diphosphate), cusbo monopotassium ah, dihydrate (9CI) CAS:72696-48-1
cusbada monopotassium-ka adenosine 5′-(trihydrogen diphosphate) oo ah dihydrate, waa isku-dhis kiimiko ah oo ka kooban adenosine oo leh koox trihydrogen diphosphate ah iyo milix monopotassium ah oo qaab dihydrate ah. Isku-darkaan waxaa badanaa loogu yeeraa adenosine diphosphate (ADP), kaas oo door muhiim ah ka ciyaara hababka kala duwan ee bayoolojiga, gaar ahaan wareejinta tamarta ee unugyada.
ADP waa qayb muhiim ah oo ka mid ah lacagta tamarta ee unugga, maadaama ay ku lug leedahay wareejinta tamarta inta lagu jiro neefsashada unugyada iyo sawir-qaadista. Sidoo kale waa hordhac u ah adenosine triphosphate (ATP), kaas oo ah side-ka ugu weyn ee tamarta ee unugyada.
Intaa waxaa dheer, ADP waxay ku lug leedahay marinnada gudbinta calaamadaha waana substrate-ka falgallada enzymatic. Marka la eego bayoolaji iyo bayoolajiga molecular, ADP waxaa si weyn loogu isticmaalaa daraasadaha la xiriira dheef-shiid kiimikaadka unugyada, kinetics-ka ensaymka, iyo hababka wareejinta tamarta.
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Hypoxanthine CAS:68-94-0 Qiimaha Soo-saaraha
Hypoxanthine waa isku-dhis dabiici ah oo dhexdhexaad ka ah burburka purines. Waa qayb muhiim ah oo ka mid ah asiidhyada nucleic-ga waxayna ku lug leedahay habab kala duwan oo bayooloji ah, oo ay ku jiraan isku-darka iyo dheef-shiid kiimikaadka DNA-da iyo RNA. Intaa waxaa dheer, hypoxanthine waxaa la ogaaday inuu door ka ciyaaro xaaladaha caafimaad qaarkood, sida gout iyo Lesch-Nyhan syndrome.
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2′-O-Methyluridine CAS:2140-76-3 Qiimaha Soo-saaraha
2′-O-Methyluridine waa nukliyoside wax laga beddelay oo ka kooban koox methyl ah oo ku taal booska 2′ ee giraanta ribose. Waa baloog dhisme oo muhiim ah oo ku jira isku-darka molecules-ka RNA ee wax laga beddelay waxaana lagu bartay sifooyinka bayoolojiga iyo dawooyinka ee suurtagalka ah. Qaar ka mid ah codsiyada la soo sheegay waxaa ka mid ah isticmaalkeeda cilmi-baarista RNA, iyadoo qayb ka ah soo saarista RNA wax laga beddelay ee loogu talagalay codsiyada daaweynta iyo kuwa shaqada, iyo qalab ahaan daraasadda qaab-dhismeedka iyo shaqada RNA.
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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS:951-77-9
2′-Deoxycytidine waa nukliyeoside ka samaysan nukliyeobase cytosine oo ku xiran sonkorta deoxyribose. Waa qayb muhiim ah oo ka mid ah DNA-da waxayna door muhiim ah ka ciyaartaa kaydinta macluumaadka hidde-sidaha iyo gudbinta noolaha nool.
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Cytidine-5′-monophosphate (CMP), aashito bilaash ah CAS:63-37-6
Cytidine 5'-monophosphate (CMP) waa nukleotide u adeegta sidii baloog dhisme oo loogu talagalay isku-darka iyo wax-ka-beddelka RNA. Waa qayb muhiim ah oo ka mid ah dhismaha molecules-ka RNA waxayna ku lug leedahay hababka sida capping mRNA iyo metabolism-ka nucleotide. CMP waxaa sidoo kale loo isticmaalaa cilmi-baarista bayoolojiga iyo molecular-ka ee codsiyada sida qoraalka in vitro iyo calaamadaynta nucleic acid. Doorkeeda dheef-shiid kiimikaadka RNA iyo isticmaalkeeda farsamooyinka tijaabada ee kala duwan ayaa ka dhigaya qalab muhiim ah oo lagu fahmo qaab-dhismeedka iyo shaqada molecules-ka RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
3-isobutyl-1-methylxanthine, oo sidoo kale loo yaqaan IBMX, waa nooc ka mid ah methylxanthine oo si caadi ah loogu isticmaalo cilmi-baarista sayniska isagoo ah joojiye aan gaar ahayn oo ka mid ah phosphodiesterases-ka cyclic nucleotide. Waxaa la ogyahay inay kordhiso heerarka gudaha ee AMP-ga wareegga ah (cAMP) iyo GMP-ga wareegga ah (cGMP) iyadoo la joojinayo burburkooda, taasoo iyaduna beddeli karta waddooyinka kala duwan ee calaamadaynta unugyada.
Marka laga soo tago codsiyada cilmi-baarista, IBMX waxaa loo isticmaalay goobo caafimaad qaarkood si loogu isticmaalo saameynteeda bronchodilator iyo vasodilator. Si kastaba ha ahaatee, isticmaalkeeda daawada aadanaha waa mid xaddidan.
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4-Nitrophenyl phosphate disodium milix hexahydrate CAS:4264-83-9
4-Nitrophenyl phosphate disodium milix hexahydrate waa isku-dhis kiimiko ah oo inta badan loo isticmaalo cilmi-baarista kiimikada iyo dawooyinka. Waa qaab cusbo ah oo ka kooban 4-nitrophenyl phosphate, oo ka kooban laba sodium ion iyo lix molecules biyo ah. Isku-darkan waxaa badanaa loo isticmaalaa sidii substrate loogu talagalay baaritaannada phosphatase iyo daraasadda kinetics-ka ensaymka.
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5′-Deoxy-5-fluorocytidine CAS:66335-38-4
5′-Deoxy-5-fluorocytidine waa nukliyeoside analoog ah oo la sameeyay oo lagu baarayo waxqabadka fayraska ee suurtagalka ah, gaar ahaan fayraska RNA sida fayraska hepatitis C (HCV) iyo flaviviruses. Waxay ka shaqeysaa faragelinta taranka walxaha hidde-sidaha fayraska, ugu dambeyntiina waxay ka hortagtaa awoodda fayrasku u leeyahay inuu ku tarmo oo ku faafo jirka dhexdiisa.
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Cytidine-5′-triphosphate (CTP), cusbo disodium ah CAS:652154-13-7
Cusbada disodium-ka ee Cytidine-5′-triphosphate (CTP), waa triphosphate nucleoside ah oo u adeegta sidii baloog dhisme oo loogu talagalay isku-darka RNA. Waxay door muhiim ah ka ciyaartaa dheef-shiid kiimikaadka unugyada waxayna lagama maarmaan u tahay wareejinta macluumaadka hidde-sidaha ee DNA-da una gudubta RNA inta lagu jiro qoraalka. CTP si weyn ayaa loogu isticmaalaa cilmi-baarista bayoolajiga molecular-ka, gaar ahaan daraasadaha la xiriira isku-darka RNA, faragelinta RNA, iyo hababka kale ee la xiriira RNA. Intaa waxaa dheer, waxaa loo isticmaalaa falcelinta enzymatic, daraasadaha dheef-shiid kiimikaadka nucleotide, iyo substrate-ka baaritaannada bayoolaji ee kala duwan. Warshadaha dawooyinka, CTP waxay sidoo kale yeelan kartaa codsiyo suurtagal ah oo ku saabsan horumarinta daawooyinka fayraska ka hortagga iyo kuwa ka hortagga kansarka.
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ITP, inosine 5′-triphosphate trisodium milix CAS:35908-31-7
Cusbada trisodium-ka Inosine-5′-triphosphate, oo inta badan loo soo gaabiyo ITP-Na3, waa qaab triphosphate ah oo inosine ah, oo ah nucleoside oo door muhiim ah ka ciyaara hababka kala duwan ee bayoolojiga. Isku-darkani waa qaab milix ah, taasoo ka dhigaysa mid biyo-milmi kara oo ku habboon in loo isticmaalo baaritaannada bayoolaji iyo enzymatic, iyo sidoo kale cilmi-baarista bayoolojiga molecular. Cusbada trisodium-ka Inosine-5′-triphosphate waxaa loo isticmaalaa barashada falgallada enzymatic, isku-beddelka nucleotide, iyo substrate ahaan enzymes-ka qaarkood. Adeegsigeedu wuxuu sidoo kale ku fidsan yahay daraasadaha analoogga nucleotide iyo qayb ka mid ah diyaarinta isku-darka nucleotide ee loo isticmaalo farsamooyinka bayoolojiga molecular.
