Boc-Nle-OHDHA CAS:21947-32-0

Boc-Nle-OH·DCHA waxay u aragtaa isticmaal ballaaran isku-darka peptide-ka marxaladda adag si loo abuuro peptides-yo gaar ah oo loogu talagalay oo leh taxane iyo shaqooyin gaar ah. Iyada oo ah qaab la ilaaliyo oo norleucine ah, waxay awood u siineysaa soo bandhigidda la xakameeyey ee haraaga norleucine silsiladda peptide-ka ee sii kordheysa, taasoo ka hortageysa falcelinta dhinaca aan loo baahnayn iyo u oggolaanshaha isku-darka peptides-ka adag oo leh sifooyin loo habeeyay. Bayoolajiga iyo bayoolajiga kiimikada, Boc-Nle-OH·DCHA waxay u adeegtaa sidii baloog dhisme oo kala duwan oo loogu talagalay abuurista peptides-ka bioactive, baaritaannada calaamadaysan, iyo daaweynta ku salaysan peptide. Isticmaalkeedu wuxuu suurtogal ka dhigayaa wax ka beddelka saxda ah ee peptides-ka iyo borotiinnada, taasoo fududeyneysa horumarinta molecules-ka badan ee shaqeynaya oo leh xasillooni la xoojiyay, gaar ahaanta bartilmaameedka, ama awoodaha sawir-qaadista ee codsiyada kala duwan ee bayoolajiga. Intaa waxaa dheer, helitaanka daawada iyo horumarinta daaweynta, Boc-Nle-OH·DCHA waxaa loo adeegsadaa in lagu abuuro isku-xidhka peptide iyo peptides-ka wax laga beddelay oo leh astaamo farmashiye-kinetic ah oo la wanaajiyey iyo hawlaha bayoolojiga. Wax-ka-beddelkani waxay kor u qaadi karaan waxtarka, xulashada, iyo keenista daawooyinka ku salaysan peptide-ka, taasoo gacan ka geysaneysa horumarinta daawada saxda ah iyo daaweynta la beegsanayo. Guud ahaan, isku halaynta iyo kala duwanaanta Boc-Nle-OH·DCHA ee isku-darka peptide iyo bioconjugation waxay ka dhigayaan qalab lama huraan ah oo lagu horumarinayo cilmi-baarista ku saabsan daahfurka daawada, bayoolajiga kiimikada, iyo proteomics, iyadoo bixinaysa fursado kala duwan oo lagu horumarinayo codsiyada biomedical-ka ee cusub.