β-Nicotinamide Mononucleotide CAS:1094-61-7

β-Nicotinamide mononucleotide (NMN) waxaa loo isticmaalaa in lagu barto qaababka isku xidhka ee ku jira aptamers-ka RNA iyo hababka kicinta ribozyme ee ku lug leh jajabyada RNA ee firfircoon ee β-nicotinamide mononucleotide (β-NMN). NMN waa nucleotide laga soo qaatay ribose iyo nicotinamide. Niacinamide (nicotinamide,) waa nooc ka mid ah fitamiin B3, oo sidoo kale loo yaqaan niacin.) Iyada oo ah horudhac bayoolaji ah oo NAD+ ah, waxay faa'iido u yeelan kartaa ka hortagga pellagra.
β-Nicotinamide mononucleotide waa dhexdhexaad ku ah biosynthesis-ka nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) wuxuu kiciyaa isku-darka nicotinamide oo leh 5-phosphoribosyl-1-pyrophosphate si loo soo saaro β-NMN, kaas oo markii dambe loo beddelo NAD+ by β-NMN adenyltransferase. 50-100 μM, β-NMN waxaa loo isticmaalay in lagu xoojiyo biosynthesis-ka NAD iyo dheecaanka insulin-ta ee gulukooska ku kiciya qaabka jiirka Nampt+/- ee cudurka dheef-shiid kiimikaadka, taasoo muujineysa door Nampt uu ku leeyahay shaqada unugyada β.