β-Nicotinamide Mononucleotide CAS: 1094-61-7

Nicotinamide mononucleotide (NMN), oo ah sheyga falcelinta NAMPT iyo furaha NAD + dhexe, waxay hagaajisaa dulqaad la'aanta gulukooska iyadoo dib u soo celinaysa heerarka NAD + ee jiirarka T2D ee HFD.NMN waxay sidoo kale wanaajisaa dareenka insulin-ta ee beerka waxayna dib u soo celisaa muujinta hidda-wadaha ee la xidhiidha diiqada oksaydhka, jawaabta bararka, iyo laxanka wareegga, qayb ahaan iyada oo loo marayo firfircoonida SIRT1.NMN waxaa loo isticmaalaa in lagu barto motifs ku xiran gudaha RNA aptamers iyo hababka firfircoonida ribozyme ee ku lug leh β-nicotinamide mononucleotide (β-NMN) -firfircoonaanta RNA.

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β-Nicotinamide mononucleotide (NMN) waxaa loo isticmaalaa in lagu barto motifs ku xiran gudaha RNA aptamers iyo hababka firfircoonida ribozyme ee ku lug leh β-nicotinamide mononucleotide (β-NMN) - jajabyada RNA firfircoon.NMN waa nucleotide ka soo jeeda ribose iyo nicotinamide.Niacinamide (nicotinamide,) waa nooc ka mid ah fitamiin B3, oo sidoo kale loo yaqaan niacin.) Sida horudhac biochemical ee NAD+, waxaa laga yaabaa inay faa'iido u leedahay ka hortagga pellagra.
β-Nicotinamide mononucleotide waa dhex dhexaad u ah biosynthesis ee nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) waxay kicisaa uumiga nicotinamide oo leh 5-phosphoribosyl-1-pyrophosphate si ay u abuurto β-NMN, kaas oo markaa loo beddelay NAD + by β-NMN adenyltransferase. NAD biosynthesis iyo dheecaanka insulin-kicinta gulukooska ee qaabka Nampt +/- jiirka ee cudurka dheef-shiid kiimikaadka, oo muujinaya doorka Nampt ee shaqada unugyada β.