Trt-Gly-OH CAS:5893-05-0

Bz-His-OMe wuxuu door muhiim ah ka ciyaaraa isku-darka peptide-ka, isagoo u adeegaya sidii baloog muhiim ah oo lagu dhiso peptides leh astaamo qaab-dhismeed iyo shaqo oo gaar ah. Kooxda ilaalinta benzyl waxay hubisaa in haraaga histidine uusan isbeddelin inta lagu jiro hababka isku-darka peptide-ka, taasoo u oggolaanaysa isu-imaatinka peptide-ka saxda ah oo la xakameeyey. Intaa waxaa dheer, joogitaanka kooxda methyl ester-ku waxay saamaysaa fal-celinta kiimikada iyo isdhexgalka hydrophobic ee peptide-ka, taasoo ka dhigaysa mid qiimo leh naqshadeynta peptides-ka leh awood-u-helidda xuubka oo la xoojiyey ama awoodaha bartilmaameedsiga gaarka ah. Horumarinta daawada, isku-darkaan waxaa loo isticmaali karaa in lagu abuuro daawooyin ku salaysan peptide oo leh xasillooni iyo helitaan bioavailability oo la wanaajiyey, taasoo keeni karta waxtarka daaweynta oo la xoojiyey. Marka laga soo tago doorkeeda ku aaddan isku-darka peptide-ka, Bz-His-OMe wuxuu helaa codsi ku saabsan cilmi-baarista proteomics iyo biochemical, halkaas oo loo isticmaali karo in lagu barto isdhexgalka borotiinka-borotiinka, lagu baaro hawlaha enzymatic-ka, iyo in la sahamiyo isbeddellada qaab-dhismeedka ku tiirsan pH-ka ee borotiinnada. Qaab-dhismeedkeeda loo habeeyay wuxuu u oggolaanayaa cilmi-baarayaasha inay baaraan isku-dhafka hababka unugyada iyo hababka cudurka, taasoo gacan ka geysanaysa horumarka fahamka caafimaadka iyo cudurada. Kala duwanaanta isku-dhafka ah iyo iswaafajinta xaaladaha tijaabada ee kala duwan ayaa ka dhigaya qayb lama huraan ah oo lagu furfurayo isku-dhafka nidaamyada bayoolojiga iyo horumarinta faragelinta bartilmaameedsan ee xaaladaha caafimaad ee kala duwan. Marka la soo koobo, Bz-His-OMe waxay u taagan tahay qalab qiimo leh oo loogu talagalay cilmi-baarayaasha ku jira isku-darka peptide, horumarinta daawada, iyo daraasadaha bayoolojiga, iyadoo bixisa awoodda lagu habeeyo peptides-ka sifooyin gaar ah iyo in la furo hababka aasaasiga ah ee hababka bayoolojiga, taasoo gacan ka geysanaysa horumarka daawada iyo bayotechnoolajiyadda.