Tofacitinib CAS: 477600-75-2 Soo saaraha

Tofacitinib waa daawo loogu talagalay daawaynta rheumatoid arthritis-ka (RA), psoriasis, cudurrada mindhicirka bararka, iyo cudurrada kale ee difaaca jirka, iyo sidoo kale ka hortagga diidmada xubinta taranka.Waa xannibaadaha enzyme Janus kinase 3 (JAK3), taas oo macnaheedu yahay inay faragelinayso dariiqa calaamadaynta JAK-STAT ee u gudbiya macluumaadka ka baxsan unugga nukleus unugga, taasoo saameynaysa qoraalka DNA-da.Dhawaan waxaa lagu muujiyay qaabka murinka ee arthritis-ka la aasaasay, tofacitinib si degdeg ah ayuu u wanaajiyey cudurka iyada oo la xakameynayo soo saarista dhexdhexaadiyeyaasha caabuqa iyo xakameynta STAT1-ku-tiirsanaanta unugyada wadajirka ah. Wadooyinka, iyagoo soo jeedinaya in tofacitinib laga yaabo inay bixiso faa'iidooyin daweyn iyada oo loo marayo dariiqooyin aan gaar u ahayn joojinta JAK3.