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5-Chloronicotinic aashito CAS:22620-27-5
5-Chloronicotinic acid waa halogenated derivative oo ka soo jeeda nicotinic acid, oo leh atamka chlorine ee booska 5-aad ee giraanta pyridine. Isku-darkani waa qayb ka mid ah fasalka ballaaran ee heterocycles-ka chlorine-ka ah wuxuuna muujiyaa sifooyin bayooloji iyo kiimiko oo muhiim ah. Waxay soo jiidatay dareenka cilmi-baarista dawooyinka ee ku saabsan codsiyada suurtagalka ah ee horumarinta daawada, gaar ahaan daaweynta cudurrada kala duwan. Joogitaanka atamka chlorine-ka wuxuu xoojiyaa fal-celinta, taasoo ka dhigaysa mid waxtar u leh isku-darka dabiiciga ah. Daraasadaha socda ayaa baaraya doorkeeda dhexdhexaadka ah ee soo saarista isku-dhafka noolaha firfircoon, iyagoo muujinaya muhiimadda ay u leedahay kiimikada daawada.
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Olopatadine Hydrochloride CAS:140462-76-6
Olopatadine hydrochloride waa daawo antihistamine ah oo inta badan loo isticmaalo daaweynta conjunctivitis-ka xasaasiyadda iyo rhinitis-ka xasaasiyadda. Iyada oo ah daawo ka hortagta soo-dhoweynta H1, waxay si wax ku ool ah u yareysaa calaamadaha sida cuncunka, casaanka, iyo indhaha oo biyo qaba iyagoo xannibaya ficilka histamine, oo ah dhexdhexaadiye kiimiko ah oo ku lug leh falcelinta xasaasiyadda. Waxaa laga heli karaa qaabab kala duwan, oo ay ku jiraan dhibcaha indhaha iyo kiniiniyada afka laga qaato, taasoo siinaysa dabacsanaan maaraynta bukaanka. Isku-darka wuxuu leeyahay muuqaal badbaado oo wanaagsan, oo leh waxyeellooyin caadi ah oo ay ku jiraan madax-xanuun iyo hurdo. Cilmi-baaris socota ayaa sii wadda inay qiimeyso waxtarkeeda iyo codsiyada suurtagalka ah ee daaweynta xaaladaha kale ee xasaasiyadda.
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2-Hydroxyisonicotinic aashito CAS:90-33-5
2-Hydroxyisonicotinic acid waa nooc ka mid ah isonicotinic acid, oo lagu garto joogitaanka koox hydroxyl ah booska labaad ee giraanta pyridine. Isku-dhafkan wuxuu muujinayaa hawlo bayooloji oo kala duwan, oo ay ku jiraan sifooyinka bakteeriyada dila iyo kuwa ka hortagga bararka. Isku ekaanshaha qaab-dhismeedka ee ka soo jeeda asiidhka nicotinic ee kale ayaa ka dhigaya bartilmaameed xiiso leh oo loogu talagalay horumarinta daawada. Cilmi-baarayaashu waxay sahaminayeen codsiyadooda kiimikada daawada, gaar ahaan daaweynta cudurrada kala duwan. Isku-dhafkan wuxuu u adeegaa sidii baloog dhisme oo lagu sameeyo molecules aad u adag wuxuuna soo jiitay dareenka dhinacyada isku-darka dabiiciga ah iyo cilmi-baarista dawooyinka.
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Methyl 2-aminopyridine-4-carboxylate CAS:6937-03-7
Methyl 2-aminopyridine-4-carboxylate waa nooc ka mid ah pyridine oo leh koox amino ah oo ku jirta booska 2-aad iyo ester carboxylate ah oo ku taal booska 4-aad, iyadoo koox methyl ah ay ku xiran tahay aashitada carboxylic. Isku-dhafkan wuxuu xiiso u leeyahay kiimikada daawada sababtoo ah waxqabadyada bayoolojiga ee suurtagalka ah, oo ay ku jiraan sifooyinka jeermiska dila iyo kuwa ka hortagga bararka. Habaynta gaarka ah ee kooxaha shaqeynaya waxay kor u qaadaysaa falcelinteeda iyo faa'iidadooda iyadoo ah dhisme isku dhafan oo ku jira isku-darka dabiiciga ah. Cilmi-baaristu waxay sii waddaa inay sahamiso codsigeeda horumarinta daawada iyo meelaha kale, iyadoo muujinaysa muhiimaddeeda gudaha kiimikada heterocyclic.
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Tofacitinib Citrate CAS:540737-29-9
Tofacitinib citrate waa daawo afka laga qaato oo lagu magacaabo Janus kinase (JAK) oo loo isticmaalo daaweynta rheumatoid arthritis, psoriatic arthritis, iyo ulcerative colitis. Waxay si xushmad leh u shaqeysaa iyadoo si xushmad leh u joojinaysa ensaymada JAK1 iyo JAK3, kuwaas oo door muhiim ah ka ciyaara dariiqooyinka calaamadaynta ee cytokines kala duwan ee ku lug leh hababka bararka. Iyada oo la adeegsanayo qaacidada molecular C16H20N6O5S·C6H8O7, tofacitinib citrate waxay muujisay waxtarka yaraynta caabuqa iyo hagaajinta tayada nolosha bukaanka. Waxaa loo oggolaaday isticmaalka kiliinikada ee dhowr waddan, cilmi-baarista socota waxay higsaneysaa inay sahamiso codsiyadeeda daaweynta ballaaran, astaanta badbaadada, iyo natiijooyinka muddada-dheer ee cudurro kala duwan oo isdifaac ah.
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Cyclen CAS: 294-90-6
Cyclen, ama 1,4,7,10-tetraazacyclododecane, waa isku-dhis polyamine ah oo caan ku ah qaab-dhismeedkiisa wareega ee gaarka ah oo leh afar atamka nitrogen oo lagu daray giraan laba iyo toban xubnood ah. Iyada oo la adeegsanayo qaacidada molecular-ka C8H16N4, cyclen wuxuu u adeegaa sidii ligand muhiim ah oo ku jira isku-dubaridka kiimikada sababtoo ah awooddiisa uu ku sameeyo isku-dhafan deggan oo leh biraha kala-guurka. Sifooyinka chelating-ka ayaa ka dhigaya mid qiimo leh codsiyada kala duwan, oo ay ku jiraan kiimikada daawada, radiopharmaceuticals, iyo kiimikada supramolecular. Cilmi-baarista socota waxay sahamisaa kartida cyclen ee nidaamyada keenista daawada iyo horumarinta wakiilada sawir-qaadista ee la beegsanayo, iyadoo xoojinaysa muhiimaddeeda sayniska aasaasiga ah iyo kan la dabaqo labadaba.
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![4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT317.png)
4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5
4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane waa isku-dhis dabiici ah oo baaskiil-wadareed ah oo lagu garto qaab-dhismeedkiisa gaarka ah oo ka kooban laba isku-xidhka ether iyo saddex atamka oksijiinta ee ku jira qaab-dhismeedka baaskiil-wadareed. Iyada oo la adeegsanayo qaacidada molecular-ka C10H16O3, isku-darkani wuxuu muujiyaa sifooyin kiimiko oo xiiso leh sababtoo ah joogitaanka labada kooxood ee methyl iyo shaqooyinka ether. Qaab-dhismeedkeeda baaskiil-wadareed wuxuu gacan ka geystaa xasilloonidiisa iyo fal-celintiisa, taasoo ka dhigaysa musharrax suurtagal ah oo loogu talagalay codsiyada kala duwan ee kiimikada dabiiciga ah ee synthetic. Cilmi-baaristu waxay sahamisaa isticmaalkeeda isku-darka molecules-ka aadka u adag iyo kartideeda ah inay noqoto baloog dhisme oo ku jira cilmiga dawooyinka iyo agabka.
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![4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1](https://cdn.globalso.com/xindaobiotech/VMLV8UWXAZ0XBLS6M290.png)
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine waa isku-dhis macmal ah oo caan ku ah codsiyada dawooyinka ee suurtagalka ah. Waxay leedahay qaab-dhismeed gaar ah oo ka kooban xudunta pyrrolopyrimidine, beddelka chloro, iyo qayb sulfonyl ah oo ku xiran kooxda para-methylphenyl. Halabuurkan qaab-dhismeedka ayaa laga yaabaa inuu gacan ka geysto dhaqdhaqaaqiisa bayoolojiga, taasoo ka dhigaysa musharrax cilmi-baaris meelaha sida kansarka ama bararka. Daraasado ayaa socda si loo sahamiyo farsamooyinka ficilka, waxtarka, iyo astaanta badbaadada, iyadoo ujeedadu tahay in la aqoonsado isticmaalkeeda daaweynta ee suurtagalka ah xaaladaha caafimaad ee kala duwan.
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3-Pyridinesulfonyl chloride CAS:16133-25-8
3-Pyridinesulfonyl chloride waa iskudhis muhiim ah oo dabiici ah oo leh qaacidada molecular-ka C6H6ClN O2S. Waa nooc ka mid ah sulfonyl chloride oo ka soo jeeda pyridine, oo leh koox shaqo oo sulfonyl chloride ah oo ku xiran booska saddexaad ee giraanta pyridine. Isku-darkaan waxaa ugu horreyn loo isticmaalaa isku-darka dabiiciga ah sida reagent si loogu soo bandhigo kooxaha sulfonyl substrates kala duwan. Falcelintiisu waxay u oggolaanaysaa inay ka qaybgasho falcelinta beddelka nucleophilic, taasoo ka dhigaysa mid qiimo leh oo ku jirta isku-darka sulfonamides iyo molecules kale oo firfircoon. Intaa waxaa dheer, 3-pyridinesulfonyl chloride waxay leedahay codsiyo suurtagal ah oo ku saabsan daawooyinka iyo kiimikooyinka beeraha.
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2-Aminoisonicotinic acid CAS:13362-28-2
2-Aminoisonicotinic acid waa nooc ka mid ah pyridine, gaar ahaan isomer-ka nicotinic acid, oo lagu garto joogitaanka koox amino ah oo ku taal booska 2-aad ee qaab-dhismeedka isonicotinic acid. Iyada oo la adeegsanayo qaacidada molecular-ka C6H6N2O2, isku-dhafkan wuxuu muujiyaa sifooyin kiimiko oo xiiso leh wuxuuna soo jiitay dareenka kiimikada daawada ee waxqabadyada bayoolojiga ee suurtagalka ah, oo ay ku jiraan saamaynta jeermiska dila iyo ka-hortagga bararka. Hawlaha amino iyo carboxylic acid waxay awood u siinayaan isbeddello kiimiko oo kala duwan, taasoo ka dhigaysa mid qiimo leh oo ku jirta isku-darka dabiiciga ah. Cilmi-baarista socota waxay sahamisaa awooddeeda daaweyneed, iyadoo iftiiminaysa muhiimadda ay u leedahay horumarinta daawada iyo codsiyada kale.
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2-Amino-4-cyanopyridine CAS:42182-27-4
2-Amino-4-cyanopyridine waa nooc ka mid ah pyridine oo lagu garto koox amino ah oo ku jirta booska 2-aad iyo koox cyano ah oo ku taal booska 4-aad ee giraanta pyridine. Iyada oo la adeegsanayo qaacidada molecular-ka C6H4N4, isku-dhafkan wuxuu muujiyaa sifooyin kiimiko oo xiiso leh iyo hawlo bayooloji oo suurtagal ah. Waxaa lagu bartay codsigeeda kiimikada daawada, gaar ahaan horumarinta daawada sababtoo ah saameynteeda bakteeriyada dila, antifungal, iyo ka-hortagga bararka. Joogitaanka labada kooxood ee shaqeynaya waxay xoojisaa falcelinteeda, taasoo ka dhigaysa mid muhiim ah oo ku jirta isku-darka dabiiciga ah. Cilmi-baaristu waxay sii waddaa inay sahamiso kala-duwanaanshaheeda dhinacyo kala duwan oo ay ku jiraan daawooyinka iyo kiimikooyinka beeraha.
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2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, ethyl ester, hydrochloride (1:1) CAS:399017-10-8
2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, ethyl ester, hydrochloride (1:1) waa nooc ka mid ah thiazole, oo lagu garto qaab-dhismeedkiisa gaarka ah oo ay ku jiraan kooxda hydroxyl, kooxda methyl, iyo ethyl ester. Isku-dhafkan wuxuu xiiso u yeeshay kiimikada daawada sababtoo ah waxqabadyada bayoolojiga ee suurtagalka ah, sida sifooyinka ka hortagga bararka iyo jeermiska dila. Qaabka cusbada hydrochloride wuxuu xoojiyaa milmida iyo xasilloonida, isagoo fududeynaya isticmaalkeeda qaacidooyinka daawada. Cilmi-baaristu waxay sii waddaa inay baarto waxtarkeeda codsiyada daaweynta ee kala duwan, taasoo ka dhigaysa musharrax qiimo leh oo loogu talagalay daraasado dheeraad ah oo ku saabsan horumarinta daawada iyo hagaajinta hogaanka.
