Orlistat CAS: 96829-58-2 Soo saaraha Soo saaraha

Orlistat waa ka hortag lipase dheefshiidka.Orlistat waxaa laga bilaabay Boqortooyada Midowday sida Xenical ee daaweynta muddada-dheer ee buurnaanta, iyadoo la doorbidayo iyada oo lala kaashanayo cunto kalooriye dhexdhexaad ah oo la dhimay.Orlistat waa tetrahydro-derivative of hypolipaemic lipstatin ee dabiiciga ah (laga bilaabo Streptomyces toxyfncini) waxaana lagu heli karaa mid ka mid ah hydrogenation of lipstatine ama dhowr siyaabood oo kala duwan oo synthetic ah oo ku lug leh tallaabooyin badan oo ka yimid (S) - rnalic acid.

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Orlistat waa mindhis-synthetic ka soo jeeda lipstatin, metabolite ka go'doon Streptomyces toxytricini.Tetrahydrolipstatin wuxuu u shaqeeyaa sidii awood xoog leh, horjooge aan laga noqon karin ee lipase ganaca.In Vivo, waxay xannibtaa nuugista triglycerides iyadoo u oggolaanaysa nuugista aashitada dufanka leh.Tetrahydrolipstatin waxaa si weyn loogu isticmaalaa daawaynta buurnida.Orlistat waxay leedahay saamayn-xakamaynta miisaanka muddada-dheer kaas oo yareeya oo ilaaliya miisaanka kana hortagaya dib u soo noqoshada.Isticmaalka Orlistat waxay hoos u dhigi kartaa dhacdooyinka khatarta ah ee la xidhiidha miisaanka iyo cudurrada, oo ay ku jiraan hypercholesterolemia, nooca-2 diabetes, dulqaadka gulukooska ee daciifka ah, hyperinsulinemia, iyo hypertension, waxayna yareyn kartaa dufanka ku jira xubnaha.