Natamycin/Pimaricin CAS:7681-93-8 Alaab-qeybiye Soo-saare

Pimaricin waa tetraene macrocyclic ah oo asal ahaan laga soocay Streptomyces natalensis sanadkii 1957. Pimaricin wuxuu muujiyaa firfircooni ballaaran oo ka dhan ah khamiirka iyo fangaska fiilada isagoo si gaar ah ugu xidhan ergosterol si uu u joojiyo koritaanka fangaska. Si ka duwan polyenes-ka la xiriira, nystatin iyo filipin, pimaricin ma beddelo marin u helka xuubka balaasmaha. Pimaricin waxaa loo isticmaalaa warshadaha cuntada si loogu daaweeyo dusha sare ee farmaajada sida ka hortagga caaryada. Natamycin waa antibiyootig polyene ah oo nus-synthetic ah. Natamycin si liidata uma milmo biyaha mana geli doono epithelium-ka corneal-ka ee buuxa. Natamycin waa wakiilka kaliya ee antifungal-ka ee loo oggolaaday in loo isticmaalo isha waana daawada kaliya ee suuqa laga heli karo ee indhaha ee lagu daweeyo keratitis-ka fangaska. Natamycin, oo sidoo kale loo yaqaan pimaracin, waxay ka tirsan tahay qoyska polyene ee antibiyootikada; (koox ka kooban wakiilo antifungal ah oo bartilmaameedsada oo ku xidha sterols-ka eukaryotic iyo gaar ahaan ergosterol), waana metabolite labaad oo ka mid ah Streptomyces natalensis.