Fmoc-Glu(OBut)-OH CAS:71989-18-9

Fmoc-Glu(OBut)-OH waxay u adeegtaa sidii qalab kala duwan oo ku jira isku-darka peptide, gaar ahaan sameynta peptides-ka ku jira glutamic acid si sax ah. Kooxda ilaalinta Fmoc waxay ilaalisaa kooxda amino, iyadoo hubinaysa falcelinta xulashada ah inta lagu jiro isku-xidhka peptide, halka kooxda butyl-ku ay ku darto lakab dheeraad ah oo ilaalin ah kooxda carboxyl. Cilmi-baarayaashu si ballaaran ayay u adeegsadaan Fmoc-Glu(OBut)-OH si ay u sameeyaan peptides-ka codsiyada kala duwan, oo ay ku jiraan horumarinta daawada, walxaha bayoolaji, iyo naqshadeynta peptides-ka firfircoon ee leh astaamo gaar ah oo qaab-dhismeed. La jaanqaadkeeda hababka isku-darka peptide-ka caadiga ah, labadaba istiraatiijiyadaha wejiga adag iyo marxaladda xalka, waxay kor u qaadaysaa kala-duwanaanshaheeda dadaallada cilmi-baarista ee kala duwan. Ka saarista la xakameeyey ee kooxaha ilaalinta waxay u oggolaanaysaa ku-darka istaraatiijiyadeed ee glutamic acid taxanaha peptide, iyadoo ballaarinaysa kala duwanaanshaha peptide-yada la isku-darka. Intaa waxaa dheer, Fmoc-Glu(OBut)-OH waxay ka heshaa faa'iido daraasadda hababka unugyada, isku-darka neuropeptide, iyo horumarinta daaweynta ku salaysan peptide. Isticmaalka istaraatiijiyadeed ee kooxda ilaalinta butyl wuxuu suurtogal ka dhigayaa in si sax ah loo maareeyo falgalka glutamic acid, isagoo siinaya cilmi-baarayaasha qalab qiimo leh oo loogu talagalay naqshadeynta peptides-ka oo leh isbeddello loo habeeyay. Marka la soo koobo, Fmoc-Glu(OBut)-OH waxay u taagan tahay aalad aasaasi ah oo aan laga maarmi karin kiimikada peptide-ka, taasoo awood siinaysa cilmi-baarayaasha inay sahamiyaan oo ay wax ka beddelaan falgalka glutamic acid ee codsiyada sayniska ee ballaaran, gaar ahaan diiradda saarista peptides-ka ka kooban amino acid-kan muhiimka ah.