Fmoc-Arg(pbf)-OH CAS:154445-77-9

Fmoc-Arg(pbf)-OH waxay u adeegtaa shaqo muhiim ah isku-darka peptide, gaar ahaan xaaladaha u baahan ilaalinta la xakameeyey ee nitrogen guanidine ee arginine. Kooxda ilaalinta Fmoc waxay ilaalisaa kooxda amino, iyadoo fududaynaysa falcelinta xulashada inta lagu jiro isku-xidhka peptide, halka kooxda pbf ee nitrogen guanidine ay bixiso lakab dheeraad ah oo ilaalin ah. Cilmi-baarayaashu waxay adeegsadaan Fmoc-Arg(pbf)-OH si ay u sameeyaan peptides-ka oo leh wax-ka-beddello gaar ah oo guanidine ah, taasoo saameynaysa hawlahooda bayoolojiga. Istaraatiijiyadda ilaalinta laba-geesoodka ah waxay suurtogal ka dhigaysaa in si sax ah loo maareeyo fal-celinta guanidine, taasoo ka dhigaysa isku-darkan mid qiimo leh naqshadeynta iyo horumarinta peptides-ka daraasadaha antimicrobial-ka, bioconjugation, iyo kiimikada daawada. Iswaafajinta Fmoc-Arg(pbf)-OH oo leh hababka isku-darka peptide-ka caadiga ah, oo ay ku jiraan isku-darka peptide-ka wejiga adag (SPPS), waxay kor u qaadaysaa waxtarkeeda. Isku-darkani wuxuu helaa codsiga dhismaha peptides-ka ee baaritaannada bayoolojiga, helitaanka daawada, iyo horumarinta agabka ku salaysan peptide. Ka saarista kooxaha ilaalinta ee la xakameeyey waxay u oggolaanaysaa in lagu daro istaraatiijiyad arginine oo leh guanidine wax laga beddelay, taasoo gacan ka geysanaysa kala duwanaanshaha peptides-ka la samayn karo. Marka la soo koobo, Fmoc-Arg(pbf)-OH waxay u taagan tahay aalad gaar ah oo kala duwan oo ku jirta kiimikada peptide-ka, taasoo awood siinaysa cilmi-baarayaasha inay sahamiyaan oo ay wax ka beddelaan falcelinta guanidine ee loogu talagalay codsiyo cilmiyeed iyo daaweyn kala duwan.