dUMP, 2′-Deoxyuridine-5′-monophosphate, cusbo disodium ah CAS:42155-08-8

Isku-darka DNA-da: dUMP waxay u adeegtaa sidii hordhac u ah deoxythymidine triphosphate (dTTP), kaas oo lagama maarmaan u ah taranka DNA-da. Beddelka dUMP ilaa dTMP waa tallaabo muhiim ah oo ku saabsan isku-darka nucleotides-ka thymidine, kuwaas oo muhiim u ah taranka saxda ah ee walxaha hidde-sidaha inta lagu jiro qaybinta unugyada.

Biyo-soo-saarista Thymidylate: dUMP waa substrate-ka enzyme-ka thymidylate synthase, kaas oo kiciya beddelka dUMP una beddela dTMP. Habkani wuxuu muhiim u yahay ilaalinta dheelitirka nucleotide ee saxda ah ee unugyada iyo hubinta daacadnimada taranka DNA-da.

Bartilmaameedka Daawada Ka-hortagga Kansarka: Thymidylate synthase, enzyme-ka ku lug leh beddelka dUMP una beddelo dTMP, waa bartilmaameed loogu talagalay daawooyinka qaarkood ee ka hortagga kansarka. Joojinta thymidylate synthase waxay carqaladeyn kartaa isku-darka DNA-da iyo taranka unugyada, taasoo ka dhigaysa bartilmaameed suurtagal ah oo loogu talagalay kiimoterabiga.

Qalabka Cilmi-baarista: dUMP waxaa loo isticmaalaa cilmi-baarista bayoolajiga iyo molecular-ka iyadoo ah substrate si loo barto hababka isku-darka DNA-da, hagaajinta, iyo dheef-shiid kiimikaadka nucleotide. Waxaa sidoo kale loo isticmaalaa baaritaannada enzymatic si loo baaro dhaqdhaqaaqa thymidylate synthase iyo ensaymes-ka la xiriira.