Candesartan CAS:139481-59-7 Alaab-qeybiye Soo-saare

Candesartan waa lid-ka-hortagga soo-dhoweeyaha angiotensin II (AT1), IC50s=1.12 iyo 2.86 nM ee kiliyaha adrenal ee lo'da iyo aorta bakaylaha siday u kala horreeyaan. Si gaar ah ayuu u joojiyaa foosha uu keeno angiotensin II ee xarigyada aorta bakaylaha iyada oo aan wax saameyn ah ku yeelan foosha ay kiciyaan wakiilada kale sida norepinephrine, KCl, serotonin, PGF2α ama endothelin.

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Codsiga iyo Saamaynta

Candesartan waa anti-ga AT1 ee la xushay (angiotensin II receptor 1). Ka soo horjeedka receptors-ka angiotensin wuxuu joojiyaa vasoconstriction iyo soo saarista aldosterone, taasoo horseedaysa hoos u dhaca fiirsashada biyaha iyo sodium ee plasma-da dhiigga. Waxay muujisaa saameyn ka hortag ah oo ka dhan ah dhiigkarka moodooyinka xayawaanka. Waxaa loo isticmaalaa daaweynta wadne xanuunka oo xirma, sida antihypertensive. Candesartan saameyn kuma yeesho jiritaanka unugyada ama faafitaanka laakiin waxay kordhisaa muujinta VEGF iyo interleukin-8 ee unugyada KU-19-19 ee la beeray. Candesartan (0.1 nM) waxay yareyn kartaa jawaabta ugu badan ee qandhada ee angiostensin II qiyaastii 50%.

Muunadda Badeecada

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Macluumaad Dheeraad ah:

Halabuurka	C24H20N6O3
Baaritaan	99%
Muuqaalka	Budada cad
Lambarka CAS.	139481-59-7
Baakad	1KG 25KG
Muddada Khafiska	2 sano
Kaydinta	Ku kaydi meel qabow oo qalalan
Shahaadada	ISO.