beta-Nicotinamide adenine dinucleotide trihydrate CAS:53-84-9

Soo saarista tamarta: β-NAD+ waa qayb muhiim ah oo ka mid ah geeddi-socodka cuntada loogu beddelayo tamar. Waxay u adeegtaa sidii coenzyme oo ku jirta neefsashada unugyada, taasoo sahlaysa wareejinta elektroonnada laga soo bilaabo metabolites-ka una gudubta silsiladda gaadiidka elektaroonigga ah. Wareejintan elektroonnada ayaa lagama maarmaan u ah soo saarista ATP, taas oo ah lacagta ugu weyn ee tamarta unugyada.

Dayactirka DNA-da: β-NAD+ wuxuu ku lug leeyahay hababka dayactirka DNA-da. Waxay u adeegtaa sidii substrate ensaymes sida PARPs (Poly [ADP-ribose] polymerases), kuwaas oo adeegsada β-NAD+ si ay u hagaajiyaan DNA-da dhaawacan iyadoo laga jawaabayo walbahaarka unugyada kala duwan sida dhaawaca DNA-da oo ay keento shucaaca, sunta, ama walbahaarka oksaydhka.

Calaamadaynta unugyada: β-NAD+ waxay soo baxday iyadoo ah molecule calaamadayn muhiim ah oo ku lug leh marinno unugyo kala duwan. Waxay u dhaqmi kartaa sidii hordhac u ah molecules calaamadayn kala duwan, sida ADP-ribose oo wareeg ah iyo NAADP, kuwaas oo nidaamiya sii deynta kalsiyum iyo gudbinta calaamadda. Intaa waxaa dheer, dheef-shiid kiimikaadka β-NAD+ wuxuu saameyn karaa muujinta hidda-wadaha, gabowga, iyo hababka kale ee jirka.

Codsiyada daaweynta: Kaabista β-NAD+ iyo habaynta heerarka β-NAD+ ayaa la baarayaa si loo helo codsiyada daaweynta ee suurtagalka ah. Daraasado dhowaan la sameeyay ayaa soo jeedinaya in kordhinta heerarka β-NAD+ ay yeelan karto saameyn faa'iido leh oo ku saabsan cudurrada la xiriira gabowga, khalkhalka neerfaha, cilladaha dheef-shiid kiimikaadka, iyo caafimaadka wadnaha iyo xididdada dhiigga. Waxaa sidoo kale jira cilmi-baaris socda oo ku saabsan isticmaalka horudhaca β-NAD+, sida nicotinamide riboside iyo nicotinamide mononucleotide, oo ah kaabis suurtagal ah si loo kordhiyo heerarka β-NAD+ ee jirka.