Amphotericin B - Heerka duritaanka CAS: 1397-89-3

Cirbadda Amphotericin B waxaa loo isticmaalaa daaweynta caabuqyada halista ah ee fangaska sida candidemia, aspergillosis-ka faafa, meningitis-ka cryptococcal, iyo mucormycosis, gaar ahaan bukaanada difaaca jirka daciifka ah ama kuwa leh habdhiska difaaca jirka oo daciif ah. Sababtoo ah firfircoonideeda xooggan ee antifungal-ka, duritaanka amphotericin B waxaa badanaa loo arkaa daaweyn safka hore ah oo loogu talagalay caabuqyada fangaska ee nidaamka daran. Xirfadlayaasha daryeelka caafimaadku waxay si taxadar leh u siiyaan amphotericin B xididka, iyagoo si taxaddar leh ula socda bukaanada inta lagu jiro duritaanka si loo maareeyo waxyeellooyinka suurtagalka ah, oo ay ku jiraan qandhada, qarqaryada, iyo falcelinta la xiriirta duritaanka. Qiyaasta iyo muddada daaweynta amphotericin B waxaa loogu talagalay infekshanka fangaska gaarka ah, xaaladda caafimaad ee bukaanka, iyo wax kasta oo cillad ah oo xubnaha hoose ah. Iyadoo la tixgelinayo sunta neerfaha iyo suurtagalnimada khalkhalka elektiroonigga, la socodka dhow ee shaqada kelyaha iyo heerarka elektiroonigga ayaa muhiim ah inta lagu jiro daaweynta amphotericin B. Qaababka lipid ee amphotericin B waxaa loo isticmaali karaa in lagu yareeyo sunta kelyaha iyo falcelinta la xiriirta duritaanka ee la xiriirta amphotericin B deoxycholate-ka caadiga ah. La socodka joogtada ah ee waxyeellooyinka, sida cilladda kelyaha iyo hoos u dhaca heerka sonkorta dhiigga, oo ay weheliso daryeel taageero oo ku habboon, ayaa gacan ka geysta maaraynta badbaadada iyo dulqaadka daaweynta amphotericin B. Bixiyeyaasha daryeelka caafimaadku waxay si taxaddar leh u miisaamaan faa'iidooyinka daaweynta iyo khataraha iman kara, iyagoo hubinaya in bukaannadu ay helaan daaweyn ku habboon oo antifungal ah iyagoo yareynaya saameynta waxyeellooyinka. Iyagoo si wax ku ool ah u bartilmaameedsanaya caabuqyada fangas ee nidaamka daran, duritaanka amphotericin B wuxuu door muhiim ah ka ciyaaraa wax ka qabashada xaaladaha halista ku ah nolosha iyo bixinta fursado daaweyn oo loogu talagalay bukaanada wajahaya cudurrada fangas ee adag.