Acetylthiocholine iodide CAS:1866-15-5

Acetylthiocholine iodide waxaa ugu horreyn loo isticmaalaa substrate si loo cabbiro dhaqdhaqaaqa enzyme acetylcholinesterase (AChE). AChE waxay mas'uul ka tahay jebinta acetylcholine neurotransmitter-ka ee nidaamka neerfaha. Ku darista acetylthiocholine iodide isku darka falgalka oo ka kooban AChE waxay horseedaa soo saarista thiocholine iyo acetate.

Falcelinta waxaa lagu ogaan karaa iyadoo lagu darayo tilmaame midab leh ama fluorometric ah oo si gaar ah ula falgala thiocholine. Heerka wax soo saarka midabka ama fluorescence wuxuu si toos ah ugu dhigmaa dhaqdhaqaaqa AChE ee muunadda. Tani waxay ka dhigaysaa acetylthiocholine iodide qalab qiimo leh oo lagu cabbiro dhaqdhaqaaqa AChE ee muunado kala duwan oo bayooloji ah, oo ay ku jiraan unugyada, dhaqamada unugyada, iyo dhiigga.

Cabbiraadda dhaqdhaqaaqa AChE iyadoo la adeegsanayo acetylthiocholine iodide ayaa si weyn loogu dabaqaa daraasadaha cilmi-baarista ee la xiriira nidaamyada cholinergic, khalkhalka neerfaha, iyo soo-gaadhista kiimikooyin ama daawooyin gaar ah oo saameyn kara dhaqdhaqaaqa AChE. Waxa kale oo loo isticmaali karaa qalab baaritaan oo lagu ogaanayo inhibitors-ka AChE, kuwaas oo xiisaynaya horumarinta daawada ee cudurada sida Alzheimers iyo Parkinson's.

Marka laga soo tago in loo isticmaalo tijaabooyinka enzymatic, acetylthiocholine iodide waxaa sidoo kale loo isticmaali karaa substrate ahaan dareemayaasha bayoolojiga ee ku salaysan AChE. Dareemayaashan bayoolojiga ah waxaa loogu talagalay inay ogaadaan oo cabbiraan jiritaanka walxo gaar ah oo joojin kara dhaqdhaqaaqa AChE, sida sunta cayayaanka ee organophosphate ama wakiilada neerfaha.