1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBIXILIC ACID CAS:113100-53-1

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid waxaa lagu sameeyaa habab kiimiko dabiici ah, oo ku lug leh falcelinta soo bandhigta atamka fluorine iyo koox methyl ah xudunta pyrazole. Molekulka ka dhasha wuxuu leeyahay astaamo qaab-dhismeed oo kala duwan oo muhiim u ah codsiyada loogu talagalay cilmiga dawooyinka iyo kiimikada. Codsiyada Daawooyinka Xaruntani waxay muujinaysaa awood daawo oo rajo leh oo loo aaneynayo qaab-dhismeedkeeda. Waxyaabaha Pyrazole ka soo jeeda waxaa caan ku ah hawlahooda kala duwan ee dawooyinka, laga bilaabo sifooyinka antimicrobial ilaa ka hortagga burooyinka. Ku darista kooxda trifluoromethyl waxay si weyn u beddeli kartaa dhaqdhaqaaqa bayoolojiga iyo xasilloonida dheef-shiid kiimikaadka, taasoo suurtogal ah inay kor u qaaddo waxtarka daawada iyo astaamaha badbaadada. Hawlaha Bayoolojiga iyo Hababka Cilmi-baaristu waxay tilmaamaysaa in isku-dhafka la beddelay ee trifluoromethyl ay badanaa muujiyaan lipophilicity la xoojiyay iyo iska caabinta dheef-shiid kiimikaadka, taasoo saameysa nuugista, qaybinta, dheef-shiid kiimikaadka, iyo soo-saarista (ADME). Wax-ka-beddelkani waxay horseedi karaan helitaanka bioavailability oo la hagaajiyay iyo saameyn daaweyn oo dheer, taasoo ka dhigaysa musharrixiin soo jiidasho leh oo loogu talagalay horumarinta daawada. Waddooyinka iyo Horumarinta Synthetic Acid-ka 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic waxay ku lug leedahay habab badan oo ka bilaabma agabka bilowga ah ee ganacsi ahaan la heli karo. Hagaajinta waddooyinka synthetic-ka waxay higsaneysaa in kor loo qaado wax soo saarka, daahirnimada, iyo ballaarinta, oo muhiim u ah codsiyada warshadaha iyo wax soo saarka baaxadda leh ee goobaha dawooyinka. Cilmi-baarista hadda jirta iyo Tilmaamaha Mustaqbalka Cilmi-baarista socota waxay diiradda saareysaa qeexidda dhammaan hawlaha bayoolojiga ee la xiriira 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. Tan waxaa ka mid ah qiimeynta waxtarkeeda bartilmaameedyada cudurrada gaarka ah iyo hagaajinta qaacidooyinka tijaabooyinka caafimaadka. Daraasadaha mustaqbalka waxay sahamin karaan awooddeeda qaab-dhismeed aasaasi ah oo loogu talagalay naqshadeynta musharixiinta dawooyinka cusub oo leh astaamo daawo oo loogu talagalay. Marka la soo koobo, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid waxay u taagan tahay horumar muhiim ah oo ku saabsan kiimikada daawada. Sifooyinka qaab-dhismeedka ee gaarka ah iyo hawlaha dawooyinka ee suurtagalka ah waxay hoosta ka xariiqayaan muhiimaddeeda oo ah mawduuc baaritaan cilmiyeed oo socda iyo hal-abuur ku saabsan horumarinta dawooyinka.