Empagliflozin CAS: 864070-44-0 Soo saaraha

Empagliflozin waa iskudhis C-glycosyl ah oo ka kooban haraaga beta-glucosyl oo leh (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl} kooxda phenyl ee xarunta anomeric. Sodium-glucose co-transporter 2 inhibitor loo isticmaalo sidii isku-darka cuntada iyo jimicsiga si loo hagaajiyo xakamaynta glycemic ee dadka qaangaarka ah ee qaba nooca 2 ee sonkorowga mellitus. Waxay leedahay door sida borotiinka gaadiidka sodium-glucose subtype 2 inhibitor iyo wakiilka hypoglycemic. Waa C-glycosyl. ka samaysan, eter caraf udgoon, ether tetrahydrofuryl ah iyo xubin ka mid ah monochlorobenzenes.

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Codsiga iyo Saamaynta

Empagliflozin waa sheeko cusub, awood leh oo la xushay SGLT-2 inhibitor, waxay hagaajisaa xakamaynta glycemic iyo astaamaha cilladda dheef-shiid kiimikaadka ee jiirka macaanka. waxa ay keentaa in sonkorta dhiiga ku jirta ay kelyuhu soo saaraan oo ay kaadida ka tirtiraanKhatarta bukaanada da'da weyn, gaar ahaan kuwa leh shaqada kelyaha ee daciifka ah iyo diuretics, waxay u muuqataa inay ka sii weyn tahay.FDA waxay u baahan tahay Boehring iyo Eli Lilly inay sameeyaan afar daraasadood oo suuq-geyn ah: dhammaystiran tijaabooyinka natiijada wadnaha iyo xididdada dhiigga, tijaabooyinka farmashiyaha carruurta iyo dawooyinka dawooyinka, badbaadada carruurta iyo waxtarka tijaabooyinka, baaritaanka sunta ee daroogada (gaar ahaan saameynta shaqada kelyaha, lafaha iyo koritaanka iyo horumarka).