2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS:86520-63-0

2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate waa isku-dhis kiimiko ah oo si caadi ah loogu isticmaalo kiimikada karbohaydraytka iyo falgallada glycosylation. Waa nooc ka mid ah α-D-galactopyranose, nooc ka mid ah sonkorta, halkaas oo kooxaha hydroxyl ee ku jira booska 2, 3, 4, iyo 6 ee giraanta galactopyranose ay yihiin acetylated. Intaa waxaa dheer, kaarboon aanomerik ahayn (C1) ee sonkorta waxaa lagu ilaaliyaa koox trichloroacetimidate ah, taasoo ka dhigaysa electrophile xooggan inta lagu jiro falgallada glycosylation.

Isku-darka waxaa badanaa loo isticmaalaa sidii wakiil glycosylating ah si loogu soo bandhigo walxaha galactose molecules kala duwan, sida borotiinnada, peptides, ama molecules-ka yaryar ee dabiiciga ah. Tan waxaa lagu gaari karaa iyadoo la falgalo isku-darkaan nucleophile (tusaale ahaan, kooxaha hydroxyl ee ku jira molecule-ka bartilmaameedka ah) xaaladaha ku habboon. Kooxda trichloroacetimidate waxay fududeysaa ku xirnaanta qaybta galactose molecule-ka bartilmaameedka ah, taasoo keenta sameynta isku-xidhka glycosidic.

Isku-darkaan waxaa si caadi ah loogu isticmaalaa isku-darka glycoconjugates, glycopeptides, iyo glycolipids. Waxay bixisaa hab wax ku ool ah oo wax ku ool ah oo loogu talagalay wax ka beddelka molecules-ka leh haraaga galactose, kuwaas oo ku habboon dhinacyo kala duwan, oo ay ku jiraan daraasaadka bayoolojiga, nidaamyada keenista daawada, ama horumarinta tallaalka.

Dalbo ama Codso Qiimayn

Faahfaahinta Badeecada

Calaamadaha Alaabta

Codsiga iyo Saamaynta

Glycosylation: Isku-darka ayaa la falgala molecules-ka aqbala ee kala duwan oo ka kooban kooxaha hydroxyl, sida alkohols ama amines, si ay u sameeyaan isku-xidhka glycosidic. Tani waxay u oggolaanaysaa in galactose la geliyo molecule-ka aqbalaha, taasoo keenta isku-darka glycoconjugates, glycopeptides, ama glycolipids.

Daraasadaha bayoolojiga iyo bayoolojiga: Isku-darkani wuxuu ka caawiyaa cilmi-baarayaasha inay bartaan shaqooyinka bayoolojiga iyo isdhexgalka molecules-ka ku jira galactose. Iyagoo si xushmad leh ugu dhejinaya galactose borotiinnada, peptides-ka, ama biomolecules-ka kale, cilmi-baarayaashu waxay baari karaan doorarkooda hababka unugyada, isdhexgalka receptor-ligand, iyo hababka cudurka.

Nidaamyada keenista daawada: Isku-darka waxaa loo isticmaali karaa in lagu beddelo molecules-ka daawada oo leh haraaga galactose, iyadoo la fududeynayo gaarsiinta daawada ee la beegsanayo unugyada ama unugyada gaarka ah. Galactose wuxuu u dhaqmi karaa sidii ligand bartilmaameedsan, isagoo aqoonsanaya soo-dhoweeyeyaal gaar ah oo lagu muujiyey dusha sare ee unugyada, gaar ahaan unugyada hepatocytes. Iyagoo ku dhejinaya galactose daawooyinka, cilmi-baarayaashu waxay kor u qaadi karaan xulashadooda iyo waxtarkooda daaweynta la beegsanayo.

Horumarinta Tallaalka: Molekulada ka kooban Galactose waxay door muhiim ah ka ciyaaraan jawaabaha difaaca jirka, maadaama lagu aqoonsado lectins-ka ku jira unugyada difaaca jirka. Iyagoo isku daraya antigens-ka qaybaha galactose iyagoo adeegsanaya isku-darkaan, cilmi-baarayaashu waxay xoojin karaan jawaab celinta difaaca jirka waxayna horumarin karaan tallaallo waxtar leh.

Isku-darka Kiimikada: Isku-darka waxaa loo isticmaali karaa isku-darka kiimikada kala duwan halkaas oo looga baahan yahay wax-ka-beddelka galactose. Tan waxaa ka mid ah diyaarinta qaab-dhismeedka karbohaydraytka ee adag, oligosaccharides, ama glycomimetics, kuwaas oo si dheeraad ah loogu isticmaali karo kiimikada daawada ama qalabka cilmi-baarista.

Muunadda Badeecada

Baakaynta Alaabta:

Macluumaad Dheeraad ah:

Halabuurka	C16H20Cl3NO10
Baaritaan	99%
Muuqaalka	Budada cad
Lambarka CAS.	86520-63-0
Baakad	Yar iyo weyn
Muddada Khafiska	2 sano
Kaydinta	Ku kaydi meel qabow oo qalalan
Shahaadada	ISO.